20 Reasons Why Latest Depression Treatments Will Never Be Forgotten > 자유게시판

• 목록
• 답변
• 글쓰기
• 게시판 리스트 옵션
  • 수정
  • 삭제

Latest Depression Treatments

The good news is that, if your depression doesn't improve after treatment with psychotherapy or antidepressants, new drugs that are fast-acting are promising for treating depression that is resistant to treatment.

SSRIs, or selective serotonin-reuptake inhibitors, are the most commonly prescribed and well-known antidepressants. They affect the way the brain uses serotonin.

Cognitive behavioral therapy (CBT) helps you change negative thoughts and behaviors such as despair. The NHS offers 8 to 16 sessions.

1. Esketamine

In March 2019, the FDA approved a brand new nasal spray for depression can be treated called esketamine. (Brand name Spravato). It is derived the anesthetic, Ketamine. This has been shown to be effective in severe depression. The nasal spray works with an oral antidepressant to treat depression that has not responded to standard medications. In one study 70 percent of those suffering from treatment-resistant depression treated with the drug had a positive response -- a far greater response rate than just an oral antidepressant.

Esketamine is different from conventional antidepressants. It boosts the levels of naturally occurring chemical in the brain, called neurotransmitters, that relay messages between brain cells. The results don't come immediately. Patients typically feel a little better after a couple of days, but the effects last much longer than with SSRIs or SNRIs. Those can take anywhere from weeks to months to take effect.

Researchers believe that esketamine reduces symptoms of depression by enhancing brain cell connections. In animal studies, esketamine reversed the breakdown of these connections that can be seen in chronic stress and depression. Additionally, it appears to promote the development of neurons that help reduce suicidal thoughts and feelings.

Another reason esketamine is different from other antidepressants is the fact that it is delivered through nasal sprays, which allows it to get into the bloodstream more quickly than a pill or oral medication could. The drug has been shown in studies to lessen depression symptoms within a couple of hours. In some cases, the effects can be immediate.

However the results of a recent study that followed patients over 16 weeks showed that not everyone who started treatment with esketamine was in Remission. This is disappointing but not unexpected, according Dr. Amit Anand, an expert on Ketamine for treatment resistant Depression but not part of the study.

Esketamine is currently only available through an experimental clinical trial or private practice. It is not considered to be a first-line treatment option for depression and is usually prescribed only when SSRIs or SNRIs haven't worked for a person with treatment-resistant depression. The doctor can determine whether the condition is resistant to treatment and then discuss whether esketamine could be beneficial.

2. TMS

TMS makes use of magnetic fields to stimulate neurons in the brain. It is noninvasive, does not require anesthesia or surgery and has been proven to improve depression in those who don't respond to medication or psychotherapy. It is also used to treat obsessive-compulsive disorder (OCD) and tinnitus.

TMS therapy for depression is typically delivered in a series of 36 daily treatments spread over six weeks. The magnetic pulses can feel like pinpricks in the scalp. It can take time to become used to. Patients can return to work and home immediately after a treatment. Based on the stimulation pattern employed the session TMS session lasts between 3.5 and 20 minutes.

Researchers believe that rTMS can alter the ways that neurons communicate. This process is referred to as neuroplasticity and allows the brain to form new connections and alter the way it functions.

TMS is FDA approved to treat depression in situations that other treatments such as medications and talk therapy have not been successful. It has also proven to be effective in treating tinnitus as well as OCD. Researchers are examining whether it could be used to treat Parkinson's disease.

TMS has been shown to improve depression in a number studies, however not every person who receives it benefits. Before you embark on this treatment, it's important to undergo an exhaustive mental and medical evaluation. If you have an history of seizures or are taking certain medications, TMS might not be right for you.

If you have been struggling with depression and are not getting the benefits from your current treatment plan, a chat with your psychiatrist might be helpful. You may be a candidate to try TMS or other forms of neurostimulation, but you need to try several antidepressants first before insurance coverage will cover the cost. Contact us today to schedule a consultation If you're interested in knowing more. Our specialists can guide you through the process of deciding if TMS is the best choice for you.

3. Deep brain stimulation

For people with treatment-resistant depression, a noninvasive therapy that rewires the brain's circuits could be effective within just a week. Researchers have devised new methods that permit them to deliver high-dose electromagnetic pulses to the brain in a shorter time and on a schedule that is more manageable for patients.

Stanford neuromodulation therapy, which is now available in the Advanced Psychiatric Therapeutics Clinic at the UC Davis Department of Psychiatry and Behavioral Sciences, uses MRI images to guide electrodes to send magnetic pulses into specific brain regions. In a recent study Mitra and Raichle discovered that in three-quarters of patients who suffer from depression, the typical flow of neural activity from the anterior cingulate cortex and the anterior insula was interrupted. SNT returned that flow to normal within a couple of days, which coincided perfectly with the lifting of depression.

Deep brain stimulation (DBS) is a more invasive procedure, can produce similar results in some patients. Neurosurgeons perform a series of tests to determine the best placement before implanting one or more leads in the brain. The leads are connected to a neurostimulator implanted beneath the collarbone, which appears to be a heart-pacemaker. The device is able to deliver an ongoing electric current through the leads. This alters the brain's natural treatment depression anxiety circuitry, decreasing depression symptoms.

Certain psychotherapy treatments can help alleviate depression symptoms, including cognitive therapy for behavioral disorders and interpersonal therapy. Psychotherapy can be offered in one-on-one sessions with an expert in mental health or in a group setting. Some therapists also provide telehealth services.

Antidepressants are the mainstay of treatment for depression. In recent years, however, there have been significant improvements in how to treat depression and anxiety without medication quickly they can help alleviate symptoms of depression. Newer drugs, such as gepirone (Exxua), esketamine (Spravato), brexanolone (Zulresso) and dextromethorphan-bupropion (Auvelity), all have been shown to work faster than older antidepressants.

Other therapies use magnetic or electric stimulation to stimulate the brain, like electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS). These are more complicated procedures that require the supervision of a doctor. In some instances, they could cause seizures or other serious adverse side effects.

4. Light therapy

Bright light therapy consists of sitting or standing in front of an artificially bright light source. This therapy has been used for a number of years to treat seasonal depression as well as major depressive disorder (SAD). Studies show that it can relieve symptoms like fatigue and sadness by regulating the circadian rhythm and boosting mood. It can also help people who experience depression that occurs and disappears.

Light therapy mimics sunlight, which is a major element of the biological clock called the suprachiasmatic nucleus (SCN). The SCN is associated with mood and light therapy may change the patterns of circadian rhythms that may contribute to depression. In addition, light therapy can reduce melatonin levels and restore the function of neurotransmitters.

Some doctors employ light therapy to combat winter blues. This is a milder type of depression treatment techniques that is similar to SAD but has fewer people affected and occurs during the seasons when there is the least amount light. They recommend sitting in front of a light therapy box each morning for 30 minutes while awake to reap the maximum benefit. Unlike antidepressants, which can take weeks to work and often cause side effects like nausea or weight gain the light therapy method can deliver results in just one week. It is also suitable for pregnant women and older adults.

Researchers caution against using light therapy without the supervision of an expert in mental health or psychiatrist, since it may cause manic episodes in those with bipolar disorders. It can also make people feel tired during the first week of treatment because it can reset their sleep-wake patterns.

PCPs must be aware of new treatments that have been approved by the FDA. However, they shouldn't ignore the tried-and-true techniques like antidepressants or cognitive behavioral therapy. Dr. Hellerstein told Healio that although the quest for newer and better treatments is exciting, we should be focusing on the most well-established treatments. He suggests that PCPs should be focusing on teaching their patients on the benefits of new treatments and assisting them adhere to their treatment strategies. This can include providing transportation to the doctor's office or setting up reminders to patients to take their medication and attend therapy sessions.